ACCOMPLISHMENTS BY FACULTY MEMBER

• BAHMAN ANVARI

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Engineering of erythrocyte-derived optical micro and nano-constructs for fluorescence imaging and phototherapeutic applications Development of optical constructs with dual optical and magnetic resonance imaging capabilities for imaging ovarian intraperitoneal tumors LEARn MORE	R. Vankayala, E. Bahena, Y. Guerrero, S. P. Singh, R. K. Murali, V. Kundra, and B. Anvari, “Virus-mimicking nanoparticles for targeted near infrared fluorescence imaging of intraperitoneal ovarian tumors: an animal model study,” Annals of Biomedical Engineering, doi: 10.1007/s10439-020-02589-8, 2020. J. C. Tang, R. Vankayala, J. Mac, and B. Anvari, “RBC-derived optical nanoparticles remain stable after a freeze-thaw cycle,”Langmuir, 36, 10003-10011, 2020.  T. M. Hanley, R. Vankayala, J. T. Mac, D. D. Lo, and B. Anvari, “The acute immune response of micro- and nanosized erythrocyte-derived optical particles in healthy mice,” Molecular Pharmaceutics, 17, 3900-3914, 2020. T. Lu, and B. Anvari, “Characterization of the viscoelastic properties of ovarian cancer cells membranes by optical tweezers and quantitative phase imaging,” Frontiers in Physics, 8, 582956, 2020. J. M. Burns, E. Shafer, R. Vankayala, V. Kundra, and B. Anvari, “Near infrared fluorescence imaging of intraperitoneal ovarian tumors in mice using erythrocyte-derived optical nanoparticles and spatially-modulated illumination,” Cancers,13, 2544, 2021. T. Hanley, R. Vankayala, C. -H. Lee, Tang, J. C. Tang, J. M. Burns, and B. Anvari, “Phototheranostics using erythrocyte-based particles,” Biomolecules, 11, 729, 2021.

   

• VASILEIOS CHRISTOPOULOS

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Reading Minds with Functional Ultrasound: A Less-Invasive Technique to Decode the Brain's Intentions Pharmacological functional ultrasound imaging to characterize the effects of NMDA-antagonist MK-801 on blood perfusion in the mouse brain: New Insights into Schizophrenia Revealing the mechanism of action underlying spinal cord stimulation for chronic back pain treatment LEARN MORE	V Enachescu, P Schrater, S Schaal, V Christopoulos, Action planning and control under uncertainty emerge through a desirability-driven competition between parallel encoding motor plans PLoS computational biology 17 (10), e1009429 Norman SL*, Maresca D*, Christopoulos VN*, Griggs WS, Demene C, Tanter M, Shapiro MG, Andersen RA. Single-trial decoding of movement intentions using functional ultrasound neuroimaging. Neuron. 2021;109(9):1554-66.e4. doi:https://doi.org/10.1016/j.neuron.2021.03.003. *Equal contribution	Invited speaker: Annual meeting of the Hellenic Society of Neuroscience, 2021

• KEVIN FREEDMAN

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Developing devices that are able to detect COVID variants Developing single molecule protein sequencing instrumentation LEARN MORE	Farajpour N, Lastra LS, Sharma V and Freedman KJ (2021) Calibration-Less DNA Concentration Measurements Using EOF Volumetric Flow and Single Molecule Counting. Front. Nanotechnol. 3:689584. Farajpour N, Lastra LS, Sharma V, Freedman KJ (2021) Measuring trapped DNA at the liquid-air interface for enhanced single molecule sensing. Nanoscale 13(11):5780-5790. Sharma V, Freedman KJ. (2021) Constricted Apertures for Dynamic Trapping and Micro-/Nanoscale Discrimination Based on Recapture Kinetics, Nano Lett. 21(8):3364-3371. Lastra LS, Sharma V, Farajpour N, Nguyen M, and Freedman KJ. (2021) Nanodiagnostics: A review of the medical capabilities of nanopores, Nanomedicine: Nanotechnology, Biology and Medicine (37): 102425.	Speaker at American Physical Society (APS March Meeting 2021)

• WILLIAM GROVER

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Developing air-powered computers for controlling soft robots Measuring the dissolution of individual granules of controlled-release pharmaceuticals Creating software tools that automate the creation of new microfluidic devices LEARN MORE	Joshua Potter, William H. Grover, and Philip Brisk. Dynamic radial placement and routing in paper microfluidics. IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 40 (10), 1971–1984 (2021). Joshua Potter, Philip Brisk, and William H. Grover. Rapid development and optimization of paper microfluidic designs using software automation. Analytica Chimica Acta 1184, 338985 (2021). Shane Hoang, Konstantinos Karydis, Philip Brisk, and William H. Grover. A pneumatic random-access memory for controlling soft robots. PLOS ONE 16 (7): e0254524 (2021). Heran C. Bhakta, Jessica M. Lin, and William H. Grover. Measuring dissolution profiles of single controlled-release drug pellets. Scientific Reports 10, 19734 (2020). Jason Ott, Daniel Tan, Tyson Loveless, William H. Grover, and Philip Brisk. ChemStor: Using formal methods to guarantee safe storage and disposal of chemicals. Journal of Chemical Information and Modeling 60 (7), 3416-3422 (2020).	Selected to join the UC Riverside Academy of Distinguished Teaching, a group formed in 2005 to "recognize the accomplishments of outstanding teachers among the UCR faculty."

• JIA GUO

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Developing arterial spin labeling, a non-invasive MRI-based method, especially velocity-selective arterial spin labeling, for blood flow imaging. LEARN MORE	DY. Chen, Y. Ishii, AP. Fan, MY. Zhao, J. Guo, GK. Steinberg, G. Zaharchuk. Predicting PET Cerebrovascular Reserve with Deep Learning using Baseline MRI: Towards a “Drug-free” Brain Stress Test. Radiology. 2020;296(3):627-37. https://doi.org/10.1148/radiol.2020192793 J. Guo, S. Das, L. Hernandez-Garcia. Comparison of velocity-selective arterial spin labeling schemes. Magn Reson Med. 2021;85(4):2027-39. https://doi.org/10.1002/mrm.28572 MY. Zhao, AP. Fan, DY. Chen, MJ. Sokolska, J. Guo, Y. Ishii, DD. Shin, MM. Khalighi, D. Holley, K. Halbert, A. Otte, B. Williams, T. Rostami, JH. Park, B. Shen, G. Zaharchuk. Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI: Impacts of arterial transit time, labeling efficiency, and hematocrit. NeuroImage. 2021;233:117955. https://doi.org/10.1016/j.neuroimage.2021.117955 Book translation: Authors: Michael Chappell, Bradley Macintosh, Thomas Okell. Translators: Xinhuai Wu, Bing Wu, Jia Guo. Introduction to perfusion quantification using arterial spin labeling. (Simplified Chinese Translation). Peking University Medical Press. Jan. 2021. ISBN: 9787565923296.	Virtual presentation at ISMRM 2021: "Ultra-fast arterial spin labeling with narrow-band velocity-selective (nb-VS) labeling."

• XIAOPING HU

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Development of multi-functional electrospun scaffolds for stem cell engineering Mechanistic understanding of stem cell behaviors under various physical stimuli Functional tissue regeneration via multiphenotypic stem cell differentiation by modulating physical microenvironments LEARN MORE	Zhang T, Huang Y, Zhao L, He Z, Jiang X, Guo L, Hu X, Liu T. Identifying cross-individual correspondences of 3-hinge gyri. Med Imag Anal 63, 2020; https://doi.org/10.1016/j.media.2020.101700. He N, Langley J, Huddleston DE, Chen S, Huang P, Ling H, Yan F, and Hu X. Increased iron-deposition in lateral-ventral substantia nigra pars compacta: A promising neuroimaging marker for Parkinson's disease. NeuroImage: Clinical 28, 2020; https://doi.org/10.1016/j.nicl.2020.102391. Langley J, Huddleston DE, Crosson B, Song D, Factor SA, and Hu X. Multimodal assessment of nigrosomal degeneration in Parkinson’s disease. Park Relat Disord 80: 102-107, 2020; https://doi.org/10.1016/j.parkreldis.2020.09.021. Wang L, Li K, and Hu X. Graph convolution network for fMRI analysis based on connectivity neighborhood. Network Neurosci 5(1): 83-95, 2021; https://doi.org/10.1162/netn_a_00171. Franco CY, Petok JR, Langley J, Hu X, and Bennett IJ. Implicit associative learning relates to basal ganglia gray matter microstructure in young and older adults. Behav Brain Res 397, 2021; https://doi.org/10.1016/j.bbr.2020.112950. Li C, Li Z, Hu X, Bachevalier J, and Zhang X. Altered hippocampal-prefrontal functional network integrity in adult macaque monkeys with neonatal hippocampal lesions. NeuroImage 227, 2021; https://doi.org/10.1016/j.neuroimage.2020.117645. Zhang X, Li C, Yan Y, Nair G, Rilling JK, Herndon JG, Preuss TM, Hu X, and Li L. In-vivo diffusion MRI protocol optimization for the chimpanzee brain and examination of aging effects on the primate optic nerve at 3T. Magn Reson Imag 77: 194-203, 2021; https://doi.org/10.1016/j.mri.2020.12.015.	“Probing Brain Dynamics and Mapping Neurodegenerative Markers with MRI.” Department of Biomedical Engineering Seminar, UT Dallas, Dallas, TX, September 2020. “Application of Machine Learning for Analyzing Resting State fMRI Data,” The 7th Qianjiang International Conference on Medical Imaging, Hangzhou, September 2020. “Recent Advances in MR Imaging of Parkinson’s Disease,” Oversea Chinese Society for Magnetic Resonance in Medicine Workshop, October 2020. “Neuroimaging Study of the Roles of Locus Coeruleus in Brain Function and Neurodegeneration,” 14th National Forum on Functional and Molecular Imaging of China, Shanghai, China, December 2020. “Tau Correlates with Tissue Susceptibility and Microstructure in APOE e4+ MCI,” The 7th Qianjiang International Conference on Medical Imaging, Hangzhou, September 2021. “Multimodal MR Imaging of Parkinson’s Disease,” China Brain Forum: Frontiers in Technology and Science of Brain, September, 2021.

• ELENA KOKKONI

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Motor intent detection through the use of EMG to control pediatric exoskeletal/wearable devices. Examination of child-robot interactions in robot-assisted contingency learning environments. Understanding the effects of mechanical support on the development of locomotion and balance.  LEARN MORE	Journal papers Kokkoni, E., Stoner, T., & Galloway, J. C. (2020). In-Home Mobility Training With a Portable Body Weight Support System of an Infant With Down Syndrome. Pediatric Physical Therapy, 32(4), E76–E82. https://doi.org/10.1097/PEP.0000000000000752 Kokkoni, E., & Galloway, J. C. (2021). User-centred assistive technology assessment of a portable open-area body weight support system for in-home use. Disability and Rehabilitation: Assistive Technology, 16(5), 505–512. https://doi.org/10.1080/17483107.2019.1683236 Conference papers Kokkoni, E., Arnold, A. J., Baxevani, K., & Tanner, H. G. (2021). Infants Respond to Robot’s Need for Assistance in Pursuing Action-based Goals. Companion of the 2021 ACM/IEEE International Conference on Human-Robot Interaction (HRI), pp. 47-51. https://doi.org/10.1145/3434074.3447126 Pacheco, C., Mavroudi, E., Kokkoni, E., Tanner, H. G., & Vidal, R. (2021). A Detection-based Approach to Multiview Action Classification in Infants. 2020 25th International Conference on Pattern Recognition (ICPR), pp. 6112-6119. https://doi.org/10.1109/ICPR48806.2021.9412822 Dechemi, A., Bhakri, V., Sahin, I., Modi, A., Mestas, J., Peiris, P., Enriquez Barrundia, D., Kokkoni, E., & Karydis, K. (2021). BabyNet: A Lightweight Network for Infant Reaching Action Recognition in Unconstrained Environments to Support Future Pediatric Rehabilitation Applications. 2021 30th IEEE International Conference on Robot & Human Interactive Communication (RO-MAN), pp. 461-467. https://doi.org/10.1109/RO-MAN50785.2021.9515507 Sahin, I., Bashir, L., Arnold, A., Tanner, H. G., & Kokkoni, E. (2021). Network Analysis of an Infant’s Motor Actions Performed in a Robot-Assisted Learning Environment. 2021 30th IEEE International Conference on Robot & Human Interactive Communication (RO-MAN), pp. 757-762. https://doi.org/10.1109/RO-MAN50785.2021.9515493

• JIAYU LIAO

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Discover essential human factor SUMOylation for influenza virus life cycle and its inhibition leads to minimal drug resistance using quantitative FRET technology; Targeting host factor for COVID-19 and influenza virus infections; Machine learning algorithms for COVID-19 recurrence analysis after combinatorial treatments.  LEARN MORE	George Way, Zhehao Xiong, Guojun Wang, Hanchu Dai, Shasha Zheng , Adolfo García-Sastre , Jiayu Liao. J Biotechnol . A novel SUMOylation site in the influenza a virus NS1 protein identified with a highly sensitive FRET assay. 2020 Nov 10;323:121-127. doi: 10.1016/j.jbiotec.2020.08.009. Jiayu Liao,⁎ George Way, and Vipul Madahar. Med Drug Discov. Target Virus or Target Ourselves for COVID-19 Drugs Discovery?―Lessons learned from anti-influenza virus therapies. 2020: doi: 10.1016/j.medidd.2020.100037 Mingyan Deng, Ling Jiang, Yan Ren, and Jiayu Liao. Med Drug Discov. Can We Reduce Mortality of COVID-19 if We do Better in Glucose Control? 2020. doi: 10.1016/j.medidd.2020.100037 Le Zheng, Oliver Wang, Shiying Hao, Chengyin Ye, Modi Li3, Minjie Xia, Alex N. Sabo, Liliana Markovic,Frank Stearns, Laura Kanov, Karl G. Sylvester, Eric Widen, Doff B. McElhinney, Wei Zhang, Jiayu Liao and Xuefeng B. Ling. Translational Psychiatry ( 2020). Development of an early-warning system for high-risk patients for suicide attempt using deep learning and electronic health records 10:72. 2. https://doi.org/10.1038/s41398-020-0684-2 Jia Huang, Le Zheng , Zhen Li, Shiying Hao , Fangfan Ye, Jun Chen , Hayley A Gans , Xiaoming Yao , Jiayu Liao , Song Wang , Manfei Zeng , Liping Qiu , Chunyang Li , John C Whitin , Lu Tian , Henry Chubb , Kuo-Yuan Hwa, Scott R Ceresnak , Wei Zhang , Ying Lu, Yvonne A Maldonado , Doff B McElhinney, Karl G Sylvester, Harvey J Cohen , Lei Liu, Xuefeng B Ling . Sci Rep. Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center. 2020 Oct 29;10(1):18629. doi: 10.1038/s41598-020-75629-x. Chuan Li, Fengming Luo, Chengwu Liu, Nian Xiong, Zhihua Xu, Wei Zhang, Ming Yang, Ye Wang, Dan Liu, Chao Yu, Jia Zeng, Li Zhang, Duo Li, Yanbin Liu, Mei Feng, Ruoyang Liu, Jiandong Mei, Senyi Deng, Zhen Zeng, Yuanhong He, Haiyan Liu, Zhengyu Shi, Meng Duan, Deying Kang, Jiayu Liao, Weimin Li & Lunxu Liu. Effect of a genetically engineered interferonalpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial. ANNALS OF MEDICINE. 2021, VOL. 53, NO. 1, 391–401. https://doi.org/10.1080/07853890.2021.1890329. Yan Liu, Yali Shen, Yang Song, Lei Xu, J. Jefferson P. Perry and Jiayu Liao. Biomolecules 2021, Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach11, 673. https://doi.org/10.3390/biom11050673. Chitra Hariharan, Fatma Zehra Kadayifci, Fan Zhang, Lei Xu, Jun Li, Shasha Zheng, Jiayu Liao. Journal of Biomedical Engineering and Biosciences (JBEB), 2021, Vol.8. Development of High Sensitive and Quantitative FRET Based Biosensor to Detect Atg4A Kinetics in Autophagy Cell Death Pathway. Patents Jiayu Liao, Zhehao Xiong, George Way. 2021, Feb. SUMOYLATION INHIBITORS AS ANTI-VIRAL AGENTS. 63149603 Jiayu Liao, Runrui Dang. 2021,Feb. METHODS FOR THE TREATMENT OF INFLUENZA. 63149574	Recognitions/Awards NSF Grant Award Number (FAIN): 2109271. Role, Co-PI. (PI Michael Pirrung) $474,000. Canadian Broadcast (CBC) News interview, The National for Tuesday. Cytokine Storms in COVID-19. 2020. Amirian Institute of Medical and Biological Engineering (AIMBE) News: Fellows: Advancing COVID-19 Efforts. NIAID/NIH COVID-19 Emergency Award Review Panels, Aug. & Dec. 2020. Review Editor, Frontiers Microbiology. Speaking Engagements 1.June, 30th, 2020. UCLA, Clinical Trail Team. Targeting host factor SUMOylation for COVID-19 treatment with multiple mechanisms. 2.Oct.10th, 2020. UCR Biomed Annual Retreat. Discover SUMOylation as a Critical Host Factor for Influenza Virus Replication. 3.Jun.22, 2020. UCR MolMed symposium. COVID-19 Drug Discovery 4.May, 7th, 2021. The Third Huaxi Health Management Summit.Predictive and Intervention Medicine Exploratory and Practice. 5.May 2nd, 2021. Peking Univ. Alumni Association. Technology Breakthroughs of COVID-19 mRNA Vaccine.

• HUINAN LIU

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Understand cell-biomaterial and tissue-biomaterial interactions in 2D and 3D Develop better tissue substitutes and medical implant materials using biodegradable polymers, ceramic nanoparticles, polymer/ceramic nanocomposites and bioresorbable metals  LEARN MORE	Changlu Xu*, Chengi Hung**, Yue Cao, and Huinan Liu. Tunable Crosslinking, Reversible Phase Transition, and 3D Printing of Hyaluronic Acid Hydrogels via Dynamic Coordination of Innate Carboxyl Groups and Metallic Ions. ACS Applied Bio Materials. 2021, 4, 3, 2408–2428. Available online February 15, 2021. DOI: 10.1021/acsabm.0c01300. Di Tie, Renguo Guan, Huinan Liu, Minfang Chen, Sviatlana A. Ulasevich, Ekaterina V. Skorb, Patricia Holt-Torres*, Xiaopeng Lu, Norbert Hort. In Vivo Degradability and Biocompatibility of a Rheo-formed Mg–Zn–Sr Alloy for Ureteral Implantation. Journal of Magnesium and Alloys. Available online January 9, 2021. DOI: 10.1016/j.jma.2020.11.005. Chunyan Zhang*^, Shiyu Zhang, Dongwei Sun*, Jiajia Lin*, Fancheng Meng, and Huinan Liu. Superhydrophobic Fluoride Conversion Coating on Bioresorbable Magnesium alloy – Fabrication, Characterization, Degradation and Cytocompatibility with BMSCs. Journal of Magnesium and Alloys. Available online 12 October 2020. DOI: 10.1016/j.jma.2020.05.017. Tie D, Liu H, Guan RG, Holt-Torres P*, Liu Y, Wang Y, and Hort N. In vivo Assessment of Biodegradable Magnesium Alloy Ureteral Stents in a Pig Model. Acta Biomaterialia. Accepted 9/11/2020. Published Online 9/16/2020. DOI: 10.1016/j.actbio.2020.09.023. (PMID: 32949824). Lin J*, Nguyen NYH*, Zhang C*, Ha A**, and Liu H. Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates. ACS Omega. 2020, 5(38): 24613–24627. Published 9/18/2020. DOI: 10.1021/acsomega.0c03151. (PMID: 33015479) Note: ACS LiveSlides™ Presentation for this article "Antimicrobial Properties of MgO Nanostructures on Magnesium Substrates" is available via this link: http://pubs.acs.org/doi/suppl/10.1021/acsomega.0c03151. Lin J*, Wang Y, Sun D*, Xue H, Guan R, and Liu H. Microstructure of Biodegradable Zn-Fe Alloys and Mechanical and Corrosion Properties. JOM-Journal of the Minerals Metals & Materials Society. Accepted 07/28/2020. Published Online 8/25/2020. DOI: 10.1007/s11837-020-04317-y.

• ROBERT MCKEE

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• JOSHUA MORGAN

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Development of vascularization strategies for human tissue equivalent Studying role of mechanical transduction in senescence Studying metabolism and signaling in aging associated ocular diseases  LEARN MORE	Schwan J, Alva TR, Nava G, Rodriguez CB, Dunn Z, Chartron JW, Morgan JT, Wang P, Mangolini L. (2021) Efficient Facemask Decontamination via Forced Ozone Convection. Scientific Reports. In Press. Preprint: Schwan J, Alva TR, Nava G, Rodriguez CB, Dunn Z, Chartron JW,Morgan JT, Wang P, Mangolini L. (2021) Efficient Facemask Decontamination via Forced Ozone Convection. arXiv:2007.09280 Sanchez MM, Morgan JT (2021) Generation of self-assembled vascularized human skin equivalents. Journal of Visual Experiments. 168. PMID: 33645584 DOI: 10.3791/62125

• JIN NAM

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Development of multi-functional electrospun scaffolds for stem cell engineering Mechanistic understanding of stem cell behaviors under various physical stimuli Functional tissue regeneration via multiphenotypic stem cell differentiation by modulating physical microenvironments  LEARN MORE	A. Banerjee, T. Jariwala, Y. Baek, D. To, Y. Tai, J. Liu, H. Park, N. V. Myung, and J. Nam (2021) Magneto- and opto-stimuli responsive nanofibers as a controlled drug delivery system. Nanotechnology 32:505101. Y. Tai, S. Yang, S. Yu, A. Banerjee, N. V. Myung, J. Nam (2021) Modulation of piezoelectric properties in electrospun PLLA nanofibers for application-specific self-powered stem cell culture platforms. Nano Energy 89:106444. Y. Tai, G. Ico, K. Low, J. Liu, T. Jariwala, D. Garcia-Viramontes, K. H. Lee, N. V. Myung, B. H. Park, J. Nam (2021) Formation of 3D Self-Organized Neuron-Glial Interface Derived from Neural Stem Cells via Mechano-Electrical Stimulation. Advanced Healthcare Materials 2100806. A. Banerjee, T. Jariwala, S. Kim, Y. Tai, S. Chiang, H. Park, N.V. Myung, J. Nam (2021) A facile method for synthesizing polymeric nanofiber-fragments. Nano Select 202100194. T. Jariwala, G. Ico, Y. Tai, H. Park, N. Myung and J. Nam (2021) Mechano-responsive piezoelectric nanofiber as an on-demand drug delivery vehicle. ACS Applied Bio Materials 4(4):3706-3715.	Elected the UCR Chapter director of NASA Space grant (Sept. 2020) Invited talk: 2021 American Association for Advances in Functional Materials (AAAFM) International Conference, Los Angeles, CA (Aug.. 2021)

• IMAN NOSHADI

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Development of highly adhesive hydrogel for Cornea tissue repair and regeneration Artificial Intelligence-powered smart bandage for chronic wound healing Biological transformation of CO2 to bioplastics  LEARN MORE	Ali Farzin,Shabir Hassan,Liliana S. Moreira Teixeira,Melvin Gurian,João F. Crispim,Varun Manhas,Aurélie Carlier,Hojae Bae,Liesbet Geris,Iman Noshadi,Su Ryon Shin,Jeroen Leijten. Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants. Adv. Funct. Mater. 31, 42, 2170308, 2021 Baishali Kanjilal, Nourouddin Sharifi, Arameh Masoumi, Iman Noshadi. Chapter 8 - Bionanofluids and mass transfer characteristics. Nanofluids and Mass Transfer, 217-244, 2022 Vaishali Krishnadoss, Baishali Kanjilal, Alexander Hesketh, Caleb Miller, Amos Mugweru, Mohsen Akbard, Ali Khademhosseini, Iman Noshadi. In situ 3D printing of implantable energy storage devices. Chemical Engineering Journal, 409, 12821, 3, 2021 Baishali Kanjilal, Mahboubeh Nabavinia, Arameh Masoumi, Mariano Savelski, Iman Noshadi. Challenges on CO2 capture, utilization, and conversion. Advances in Carbon Capture, 29-48, 2020 Baishali Kanjilal, Arameh Masoumi, Mahboubeh Nabavinia, Vaishali Krishnadoss, Mariano Savelski, Iman Noshadi, CO2 adsorption by carbonaceous materials and nanomaterials, Advances in Carbon Capture, 173-192, 2020

• GIUILA PALERMO

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9 Mechanistic investigation of DNA cleavage and specificity in CRISPR- Cas9  LEARN MORE	J. Manigrasso, M. De Vivo and G. Palermo.* Controlled Trafficking of Multiple Cations Prompts Nucleic Acid Hydrolysis in RNase H1. ACS Catalysis 2021, 11, 8786–8797. Journal Cover Art. N.T. Zewde, R.V. Hsu. D. Morikis* and G. Palermo.* Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens. Front. Phys. 2021, 9, 9, 603704. Ł. Nierzwicki and G. Palermo.* Molecular Dynamics to predict Cryo-EM: capturing transitions and short-lived conformational states of biomolecules. Front. Mol. Biosci. 2021, 8:641208. J. Wang,† P. R. Arantes,† A. Bhattarai, R. V. Hsu, S. Pawnikar, Y. M. Huang, G. Palermo* and Y. Miao.* Gaussian accelerated molecular dynamics (GaMD): principles and applications. WIREs Comp. Mol. Sci. 2021, e1521. N. Farag, R. Mattossovich, R. Merlo, Ł. Nierzwicki, G. Palermo, A. Porchetta,* G. Perugino* and F. Ricci.* Activity-based monitoring of DNA repair enzymes using programmable Triplex-forming nanoswitches. Angew. Chem. Int. Ed. 2021, 133, 2–9. Y. B. Y.B. Narkhede,† A. K. Gautam,† R. V. Hsu,† W. Rodriguez,† N. T. Zewde, R. E. S. Harrison, P. R. Arantes, Z. Gaieb, R. D. Gorham Jr, C. Kieslich, D. Morikis, A. Sahu* and G. Palermo.* Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins toward Human and Bovine Complement Inhibition. Front. Mol. Biosci. 2021, 8:618068. G. Palermo, A. Spinello, A. Saha and A. Magistrato.* Frontiers of molecular dynamics simulations to design metal-coordinating drugs. Expert Opin. Drug. Discov. 2021, 16, 497–511. L. Casalino, Ł. Nierzwicki, M. Jinek and G. Palermo.* Catalytic Mechanism of Non-Target DNA Cleavage Revealed by Ab-Initio Molecular Dynamics. ACS Catalysis 2020, 22, 13596–13605. Journal Cover Art A. Saha,† P. R. Arantes,† R. V. Hsu, Y. B. Narkhede, M. Jinek and G. Palermo.* Molecular Simulations Reveal a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a. J. Chem. Inf. Model. 2020, 60, 6427–6437. Journal Cover Art. ACS Editor’s Choice. Ł. Nierzwicki, P. R. Arantes, A. Saha and G. Palermo.* Establishing the Allosteric Mechanism in CRISPR-Cas9. WIREs Comput. Mol. Sci. 2020, e1503. Journal Cover Art. P. R. Arantes, A. Saha and G. Palermo.* Fighting COVID-19 using Molecular Dynamics Simulations. ACS Cent. Sci. 2020, 5, 651-662. J. Cui, F. Zhang, Ł. Nierzwicki, G. Palermo, R. Linhardt and G. P. Lisi.* Mapping the Structural and Dynamic Determinants of pH-sensitive Heparin Binding to Granulocyte Macrophage-colony Stimulating Factor. Biochemistry 2020, 59, 3541–3553.	Awards 2021/09 | Corwin Hansch Award to outstanding scientists under 40, for significant contributions to the field of computational drug design. Hansch-Fujita Foundation 2021/09 | Featured in the 2021 J. Am. Chem. Soc. Early Career Investigators Issue 2021/06 | First place prize at the 2021 RNA Society Arts and Music competition Speaking Engagements 2021/06 | Invited talk at the University of California San Diego (virtual) 2021/05 | Invited talk at Brookhaven National Lab (virtual) 2021/05 | Student invited talk at the University of California Los Angeles (virtual) 2021/04 | Invited talk at Rutgers University (virtual) 2020/10 | Invited talk at the Illinois Institute of Technology (virtual)

• HYLE PARK

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• VICTOR G.J. RODGERS

  TOP RESEARCH PROJECTS	PUBLICATIONS	RECOGNITIONS AND ENGAGEMENTS
  Devices to reduce edema for central nervous system Injury Crowded protein thermodynamics Systems biology analysis of hydrogen peroxide in cancer treatment  LEARN MORE	Terry TL, Givens BE, Adamcakova-Dodd A, Thorne PS, Rodgers VGJ, Salem AK (2021) Encapsulating polyethyleneimine-DNA nanoplexes into PEGylated biodegradable microparticles increases transgene expression in vitro and reduces inflammatory responses in vivo. AAPS PharmSciTech, 2021 Feb 9;22(2):69. doi: 10.1208/s12249-021-01932-z. Hale CS, Yonan JM, Batarseh R, Chaar R, Jonak CR, Binder DK, Rodgers VGJ (2020) Implantable Osmotic Transport Device Can Reduce Edema After Severe Contusion Spinal Cord Injury, Frontiers in Bioengineering and Biotechnology: Biomechanics, Vol. 8, Page 806, DOI https://doi.org/10.3389/fbioe.2020.00806. Erudaitius DT, Buettner GR, Rodgers VGJ (2020) The latency of peroxisomal catalase in terms of effectiveness factor for pancreatic and glioblastoma cancer cell lines in the presence of high concentrations of H2O2: Implications for the use of pharmacological ascorbate in cancer therapy, Free Radical Biology and Medicine, Volume 156,Pages 20-25, ISSN 0891-5849,https://doi.org/10.1016/j.freeradbiomed.2020.05.023.	Bioengineering Perspectives for Chaffey College Students, Chaffey College, October 23, 2021 Treatments for Severe Edema of the Central Nervous System Using Osmotic Pressure, UC Irvine, Department of Biomedical Engineering, May 7, 2021

• VALENTINE VULLEV

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FACULTY DIRECTORY

• CORE FACULTY

• COOPERATING FACULTY